Aite's Sword - You're going to get hit.Even worse, the double damage also applies to the Blessing of Life, making the biggest risk you'll take outside of the boss room even riskier! And then you'll get wrecked by a boss in three hits when they fill the screen with damage you can't dodge because this is True Rogue, you are slow and only have one extra jump and one dash. The Serrated Handle's Bargain - This Relic is a trap! Take it and you'll be thrilled with how you can zoom through the Biome itself, wrecking baddies left and right.Hyperion's Ring - Think of this as a 50% heal in the final boss gauntlet.Stay invincible longer and do tons of damage in the meantime. Rage Tincture + Ambrosia - Nearly self-explanatory, this classic relic combo holds its power in True Rogue too.And thanks to the three new Relic rooms just before the final boss that appear in all modes you can decide exactly how much HP reduction you can accept for a huge damage increase in the final fight. Raven's Ring - Overwhelmingly likely to be a pure damage increase through the majority of your True Rogue run, especially after the first biome.

The Measure is better if you are wielding a weapon that you can use to reliably skill crit. Freon's Reward OR Lachesis' Measure - You'll need a source of sustain in True Rogue, and the health-drop-related relics just aren't reliable enough.

Once you have the shell, stumbling upon a fruit room will the a very happy moment - go charge the shell with six enemies, scoot right back to the fruit room, and get your HP increase with zero downside.

Coeus' Shell - This relic shows its biggest impact out of battle by preventing the damage from picking up a Blessing of Life.

Catalyst - IF you get a source of status effect (from a weapon, a relic, or your base class), Catalyst acts as a pure damage increase.

Yes, you'll have to be more careful about Hazards, but to have a prayer in True Rogue you're probably pretty darn good at avoiding those anyway.

Tattered Rope - In a mode all about stacking Relics, netting 50 Resolve is always going to be nice.

It serves as a pure damage boost with no downside that will continue to scale through your entire run.

War Drum - War Drum is a staple of normal mode and only gets better in True Rogue.

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